Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC063
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-11-16 11:09
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment tbl Madopar a 250mg 3x1/2 tbl PK Mertz a 100mg 1+1+0 tbl Mirapexin a 3,25mg 1x1 old patient

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 11 individuals with a value less than 0.55 were subsequently diagnosed with PD. That is, 26.19% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.55 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 18, 'TN': 13, 'TP': 24, 'FP': 17}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 24, 'TN': 20, 'TP': 18, 'FP': 10}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 17, 'TN': 9, 'TP': 25, 'FP': 21}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 30, 'TN': 20, 'TP': 12, 'FP': 10}

Test Battery Details

Circle

numCircles 13
timePerCircleMean 7.56
timePerCircleCoV 0.146214
timePerCircleSlope 0.00537822
meanError 1.5067
tremorFreq 6.25
tremorRelPower 59.2252
tremorGyroAmpMean 0.232011
tremorGyroAmpSlope -0.00395088
tremorGyroAmpCoV 0.412537
tremorCoordAmpMean 0.314589
tremorCoordAmpSlope -0.00399332
tremorCoordAmpCoV 0.421193
tremorAccAmpMean 0.289044
tremorAccAmpSlope -0.00360982
tremorAccAmpCoV 0.379389
tremorPcRelVar 0.886688
tremorPcX 0.803877
tremorPcY 0.594795

Circle Segment 1

Duration 7.8 s, Accuracy Estimate 1.721 (lower is better)

Circle Segment 2

Duration 8.68 s, Accuracy Estimate 1.381 (lower is better)

Circle Segment 3

Duration 7.56 s, Accuracy Estimate 1.596 (lower is better)

Circle Segment 4

Duration 6.6 s, Accuracy Estimate 1.61 (lower is better)

Circle Segment 5

Duration 6.96 s, Accuracy Estimate 1.379 (lower is better)

Circle Segment 6

Duration 6.36 s, Accuracy Estimate 1.48 (lower is better)

Circle Segment 7

Duration 6.68 s, Accuracy Estimate 1.297 (lower is better)

Circle Segment 8

Duration 7.28 s, Accuracy Estimate 1.533 (lower is better)

Circle Segment 9

Duration 7.08 s, Accuracy Estimate 1.546 (lower is better)

Circle Segment 10

Duration 8.16 s, Accuracy Estimate 1.503 (lower is better)

Circle Segment 11

Duration 10.52 s, Accuracy Estimate 1.63 (lower is better)

Circle Segment 12

Duration 7.68 s, Accuracy Estimate 1.484 (lower is better)

Circle Segment 13

Duration 6.92 s, Accuracy Estimate 1.427 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 24.288
timePerSpiralCoV 0.166732
timePerSpiralSlope 0.0358526
meanError 2.05933
tremorFreq 5.85938
tremorRelPower 78.9904
tremorGyroAmpMean 0.496743
tremorGyroAmpSlope 0.00172329
tremorGyroAmpCoV 0.347551
tremorCoordAmpMean 0.390517
tremorCoordAmpSlope -5.09639e-05
tremorCoordAmpCoV 0.384505
tremorAccAmpMean 0.375559
tremorAccAmpSlope 0.00087194
tremorAccAmpCoV 0.366046
tremorPcRelVar 0.87159
tremorPcX 0.791851
tremorPcY 0.610715

Spiral Segment 1

Duration 17.0 s, Accuracy Estimate 2.334 (lower is better)

Spiral Segment 2

Duration 19.88 s, Accuracy Estimate 1.895 (lower is better)

Spiral Segment 3

Duration 26.28 s, Accuracy Estimate 2.097 (lower is better)

Spiral Segment 4

Duration 24.68 s, Accuracy Estimate 2.018 (lower is better)

Spiral Segment 5

Duration 25.8 s, Accuracy Estimate 1.836 (lower is better)

Spiral Segment 6

Duration 25.56 s, Accuracy Estimate 1.943 (lower is better)

Spiral Segment 7

Duration 21.08 s, Accuracy Estimate 1.951 (lower is better)

Spiral Segment 8

Duration 29.56 s, Accuracy Estimate 2.415 (lower is better)

Spiral Segment 9

Duration 23.44 s, Accuracy Estimate 2.083 (lower is better)

Spiral Segment 10

Duration 29.6 s, Accuracy Estimate 2.022 (lower is better)

Elel

eDurationMean 0.312778
eDurationStd 0.0457859
eDurationStdnorm 0.146385
eDurationMedian 0.3125
eDurationQuartdelta 0.0625
eDurationQuartdeltanorm 0.2
eDurationKurt 2.7154
eDurationTrenddiff -0.05
eDurationTrendratio 0.850746
eWidthMean 3.926
eWidthStd 1.52663
eWidthStdnorm 0.388852
eWidthMedian 3.9195
eWidthQuartdelta 1.8135
eWidthQuartdeltanorm 0.462687
eWidthKurt 2.75389
eWidthTrenddiff -0.234
eWidthTrendratio 0.941176
eHeightMean 6.63325
eHeightStd 1.97307
eHeightStdnorm 0.297452
eHeightMedian 6.552
eHeightQuartdelta 2.5155
eHeightQuartdeltanorm 0.383929
eHeightKurt 2.74044
eHeightTrenddiff -1.287
eHeightTrendratio 0.822581
eAspectMean 0.590938
eAspectStd 0.15635
eAspectStdnorm 0.264579
eAspectMedian 0.569805
eAspectQuartdelta 0.193819
eAspectQuartdeltanorm 0.340149
eAspectKurt 2.40639
eAspectTrenddiff 0.0638526
eAspectTrendratio 1.11367
eSlantMean 0.0234705
eSlantStd 0.203998
eSlantStdnorm 8.69167
eSlantMedian 0
eSlantQuartdelta 0.290855
eSlantQuartdeltanorm 12.3924
eSlantKurt 2.68162
eSlantTrenddiff 0.087398
eRtopMean 0.755254
eRtopStd 0.225557
eRtopStdnorm 0.298651
eRtopMedian 0.8
eRtopQuartdelta 0.294673
eRtopQuartdeltanorm 0.368341
eRtopKurt 5.12111
eRtopTrenddiff 0.0483525
eRbotMean 0.750938
eRbotStd 0.317425
eRbotStdnorm 0.422704
eRbotMedian 0.68609
eRbotQuartdelta 0.401387
eRbotQuartdeltanorm 0.585036
eRbotKurt 3.31513
eRbotTrenddiff -0.110283
eRrightMean 0.847399
eRrightStd 0.131008
eRrightStdnorm 0.1546
eRrightMedian 0.877885
eRrightQuartdelta 0.176128
eRrightQuartdeltanorm 0.200628
eRrightKurt 3.14416
eRrightTrenddiff 0.0393702
eRleftMean 0.425971
eRleftStd 0.198712
eRleftStdnorm 0.466493
eRleftMedian 0.423456
eRleftQuartdelta 0.259568
eRleftQuartdeltanorm 0.612975
eRleftKurt 3.84444
eRleftTrenddiff 0.084355
lDurationMean 0.383333
lDurationStd 0.0423152
lDurationStdnorm 0.110388
lDurationMedian 0.38
lDurationQuartdelta 0.055
lDurationQuartdeltanorm 0.144737
lDurationKurt 2.96952
lDurationTrenddiff -0.03
lDurationTrendratio 0.924528
lWidthMean 4.80187
lWidthStd 1.72386
lWidthStdnorm 0.358996
lWidthMedian 4.5045
lWidthQuartdelta 1.8135
lWidthQuartdeltanorm 0.402597
lWidthKurt 3.94023
lWidthTrenddiff 0.234
lWidthTrendratio 1.05479
lHeightMean 14.2253
lHeightStd 2.03146
lHeightStdnorm 0.142807
lHeightMedian 14.6835
lHeightQuartdelta 2.574
lHeightQuartdeltanorm 0.175299
lHeightKurt 3.19408
lHeightTrenddiff -1.053
lHeightTrendratio 0.930502
lAspectMean 0.337252
lAspectStd 0.101792
lAspectStdnorm 0.301828
lAspectMedian 0.329487
lAspectQuartdelta 0.122431
lAspectQuartdeltanorm 0.371579
lAspectKurt 2.88481
lAspectTrenddiff -0.0282834
lAspectTrendratio 0.919646
lSlantMean 0.0823902
lSlantStd 0.111073
lSlantStdnorm 1.34813
lSlantMedian 0.0983635
lSlantQuartdelta 0.111718
lSlantQuartdeltanorm 1.13577
lSlantKurt 3.95175
lSlantTrenddiff 0.0679438
lRtopMean 0.861225
lRtopStd 0.132528
lRtopStdnorm 0.153883
lRtopMedian 0.89677
lRtopQuartdelta 0.185735
lRtopQuartdeltanorm 0.207116
lRtopKurt 2.90275
lRtopTrenddiff 0.142658
lRbotMean 0.61491
lRbotStd 0.308888
lRbotStdnorm 0.50233
lRbotMedian 0.5125
lRbotQuartdelta 0.296372
lRbotQuartdeltanorm 0.578287
lRbotKurt 5.81348
lRbotTrenddiff -0.0240762
lRrightMean 0.921513
lRrightStd 0.0952934
lRrightStdnorm 0.10341
lRrightMedian 0.934259
lRrightQuartdelta 0.0997848
lRrightQuartdeltanorm 0.106806
lRrightKurt 5.25419
lRrightTrenddiff 0.0320289
lRleftMean 0.312313
lRleftStd 0.116528
lRleftStdnorm 0.373114
lRleftMedian 0.315751
lRleftQuartdelta 0.144691
lRleftQuartdeltanorm 0.458244
lRleftKurt 2.31719
lRleftTrenddiff -0.04843

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

FITTS Short Modified

meanTouchScore 0.618668
sumTouchScores 21.6534
meanMovementTime 0.557059
numTouches 35
undershootPercentage 0
overshootPercentage 48.5714

FITTS Long Modified

meanTouchScore 0.598802
sumTouchScores 13.7724
meanMovementTime 0.862273
numTouches 23
undershootPercentage 4.34783
overshootPercentage 26.087

ZigZag

numZigzags 5
timePerZigzagMean 19.112
timePerZigzagCoV 0.173059
timePerZigzagSlope 0.100042
meanError 2.44453
tremorFreq 6.05469
tremorRelPower 74.73
tremorGyroAmpMean 0.34395
tremorGyroAmpSlope 0.00538043
tremorGyroAmpCoV 0.297583
tremorCoordAmpMean 0.312951
tremorCoordAmpSlope -0.00320058
tremorCoordAmpCoV 0.328988
tremorAccAmpMean 0.304114
tremorAccAmpSlope 4.60244e-06
tremorAccAmpCoV 0.319217
tremorPcRelVar 0.825507
tremorPcX 0.805905
tremorPcY -0.592045

ZigZag Segment 1

Duration 14.44 s, Accuracy Estimate 2.785 (lower is better)

ZigZag Segment 2

Duration 16.92 s, Accuracy Estimate 2.428 (lower is better)

ZigZag Segment 3

Duration 21.48 s, Accuracy Estimate 2.395 (lower is better)

ZigZag Segment 4

Duration 20.52 s, Accuracy Estimate 2.147 (lower is better)

ZigZag Segment 5

Duration 22.2 s, Accuracy Estimate 2.468 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 10.056
timePerZigzagCoV 0.114341
timePerZigzagSlope -0.0644391
zigzagHeightMean 61.8985
zigzagHeightCoV 0.0432327
zigzagHeightSlope -0.0251739
meanError 0.0410916
tremorFreq 6.25
tremorRelPower 63.6275
tremorGyroAmpMean 0.262711
tremorGyroAmpSlope 0.00164491
tremorGyroAmpCoV 0.331035
tremorCoordAmpMean 0.273127
tremorCoordAmpSlope 0.00338836
tremorCoordAmpCoV 0.328694
tremorAccAmpMean 0.25269
tremorAccAmpSlope 0.00307489
tremorAccAmpCoV 0.297473
tremorPcRelVar 0.662052
tremorPcX -0.781088
tremorPcY 0.624421

ZigZag Offset Segment 1

Duration 11.32 s, Accuracy Estimate 0.037 (lower is better)

ZigZag Offset Segment 2

Duration 10.6 s, Accuracy Estimate 0.031 (lower is better)

ZigZag Offset Segment 3

Duration 9.84 s, Accuracy Estimate 0.035 (lower is better)

ZigZag Offset Segment 4

Duration 10.28 s, Accuracy Estimate 0.046 (lower is better)

ZigZag Offset Segment 5

Duration 8.24 s, Accuracy Estimate 0.057 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.81}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.55}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9831346515929786}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9258963626266676}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.5902799076172822}